The Blair laboratory studies developmental patterning, using
as a model system the wing of the fruitfly, Drosophila melanogaster.
The laboratory uses a combination of molecular genetic and
biochemical techniques to examine the roles of cell lineage
and cell signaling in the choice of cell fate in the developing
wing epithelium. In recent years our work has centered around
1) the bases of “compartmental” lineage restrictions;
2) the extracellular modulation of the BMP and Hedgehog signaling
pathways by novel ligand-binding proteins, and 3) the regulation
of growth, proximo-distal patterning and planar cell polarity
by the large protocadherins Dachsous and Fat.
Zoology 151 - Introductory Biology
Zoology 523 - Neurobiology
Zoology 625 - Development of the Nervous System
Zoology 965 - Seminars in Developmental Biology
Graduate students currently supervised:
Olson ( firstname.lastname@example.org )
Zoology Ph.D. student - The identification
and characterization of detached mutations, and their roles
in crossvein development and BMP signaling in Drosophila.
S. Avanesov ( email@example.com )
Genetics Ph.D. student - Hedgehog signaling and
compartmentalization during wing disc development in the
wing of Drosophila.
Chen ( firstname.lastname@example.org )
Genetics Ph.D. student - The role of cv-2 and cv-d mutants in
BMP signaling in the formation of the crossveins of Drosophila.
Graduate students supervised who earned graduate
Craig Micchelli (Ph.D. Neuroscience Training Program, 1999)
Mechanisms of pattern formation
in the wing imaginal disc of Drosophila : A study of
cell signaling at the dorso-ventral boundary using genetic
Catherine Conley (Ph.D. Zoology, 2000) Abstract
Molecular and genetic analysis of
cross vein patterning in the wing of Drosophila melanogaster.
Amy Ralston (Ph.D. Zoology, 2004) Abstract
The role of signaling pathways in
the specification of veins and lineage boundaries in the
wing of Drosophila .
Catherine A. Miller (Ph.D. CMB, 2004)
shifted , the Drosophila homolog of the
human Wnt inhibitory factor 1, is involved in the Hedgehog
W. Elizabeth Jones (M.S. CMB, 2004)
The cv-d and det loci: mapping and characterization
of genetic interactions with the crossveinless loci cv, cv-2
O'Connor, M.B., Umulis, D., Othmer, H. and Blair, S.S.
(2006). Shaping BMP morphogen gradients in the Drosophila
embryo and pupal wing. Development 133, 183-193
Shimmi, O.*, Ralston, A.*, Blair, S.S., and O'Connor, M.B.
(2005). The crossveinless gene encodes a new member of the
Twisted gastrulation family of BMP binding proteins which,
with Short gastrulation, promotes BMP signaling in the crossveins
of the Drosophila wing. Dev. Biol. 282, 70-83. (*co-first
Serpe, M., Ralston, A., Blair, S.S., and O'Connor, M.B.
(2005). Matching catalytic activity to developmental function:
Tolloid-related processes Sog to help specify the posterior
crossvein in the Drosophila wing. Development 132, 2645-2656.
Ralston, A., and Blair, S.S. (2005). Long-range Dpp signaling
is regulated to restrict BMP signaling to a crossvein competent
zone. Dev. Biol. 280, 187-200.
Blair, S.S. (2005). Cell Signaling: Wingless and Glypicans
together again. Curr. Biol. 15, R92-R94.
Glise, B.*, Miller, C.A.*, Crozatzier, M., Halbisen, M.A.,
Wise, S., Olson, D., Vincent, A., and Blair, S.S. (2005).
Shifted, the Drosophila orthologue of Wnt Inhibitory Factor-1,
controls the distribution and movement of Hedgehog. Dev.
Cell 8, 255-266. (*co-first authors)
Blair, S.S. (2000b). Notch signaling: Fringe really is
a glycosyltransferase (invited Dispatch). Current Biol. 10,
Conley, C.A., Silburn, R., Singer, M.A., Ralston, A., Rohwer-Nutter,
D., Olson, D.J., Gelbart, W. and Blair, S.S. (2000). Crossveinless
2 contains cysteine-rich domains and is required for high
levels of BMP-like activity during the formation of the cross
veins in Drosophila . Development 127, 3947-3959.
Micchelli, C.A. and Blair, S.S. (1999). Dorso-ventral lineage
restriction in wing imaginal discs requires Notch. Nature
Blair, S.S. (1999). Drosophila imaginal disc development:
patterning the adult fly. In Development-Genetics, Epigenetics
and Environmental Regulation , (V.E.A. Russo, D. Cove, L.
Edgar, R. Jaenisch, F. Salamini, eds), Chpt. 21, pp. 347-370.